Publications

See the full publications list on PubMed.

2024

• Ladak RJ, Choi JH, Luo J, Chen OJ, Mahmood N, He AJ, Naeli P, Snell PH, Bayani E, Hoang HD, Alain T, Teodoro JG, Wang J, Zhang X*, Jafarnejad SM*, Sonenberg N*. The 4EHP-mediated translational repression of cGAS impedes the host immune response against DNA viruses. Proc Natl Acad Sci U S A. 2024 Nov 26;121(48):e2413018121. *Joint corresponding authors

• Chatterjee S, Naeli P, Onar O, Simms N, Garzia A, Hackett A, Coyle K, Harris Snell P, McGirr T, Sawant TN, Dang K, Stoichkova ZV, Azam Y, Saunders MP, Braun M, Alain T, Tuschl T, McDade SS, Longley DB, Gkogkas CG, Adrain C, Knight JRP, Jafarnejad SM. Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil. Nucleic Acids Research. 2024 Nov 11;52(20):12534-12548.

• Choi JH, Luo J, Hesketh GG, Guo S, Pistofidis A, Ladak RJ, An Y, Naeli P, Alain T, Schmeing TM, Gingras AC, Duchaine T, Zhang X*, Sonenberg N*, Jafarnejad SM*. Repression of mRNA translation initiation by GIGYF1 via disrupting the eIF3-eIF4G1 interaction. Science Advances. 2024 Jul 19;10(29):eadl5638. *Joint corresponding authors

• Lister KC, Wong C, Uttam S, Parisien M, Stecum P, Brown N, Cai W, Hooshmandi M, Gu N, Amiri M, Beaudry F, Jafarnejad SM, Tavares-Ferreira D, Inturi NN, Mazhar K, Zhao HT, Fitzsimmons B, Gkogkas CG, Sonenberg N, Price TJ, Diatchenko L, Atlasi Y, Mogil JS, Khoutorsky A. Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain. eLife. 13:RP100451

• McGirr T, Onar O, Jafarnejad SM. Dysregulated ribosome quality control in human diseases. FEBS J. 2024 Jul 1.

• Smith MR, Naeli P, Jafarnejad SM, Costa G. The scaffolding protein AKAP12 regulates mRNA localization and translation. Proc Natl Acad Sci U S A. 2024 Apr 30;121(18):e2320609121.

2023

• Naeli P, Zhang X, Snell PH, Chatterjee S, Kamran M, Ladak RJ, Orr N, Duchaine T, Sonenberg N, Jafarnejad SM. The SARS-CoV-2 protein NSP2 enhances microRNA-mediated translational repression. J Cell Science. 2023 Oct 1;136(19):jcs261286.

• Escós A, Diaz-Mora E, Pattison M, Fajardo P, González-Romero D, Risco A, Martín-Gómez J, Bonneil É, Sonenberg N, Jafarnejad SM, Sanz-Ezquerro JJ, Ley SC, Cuenda A. p38γ and p38δ modulate innate immune response by regulating MEF2D activation. Elife. 2023 Jul 17;12:e86200.

• Accogli A, Lin SJ, Severino M, Kim SH, Huang K, Rocca C, Landsverk M, Zaki MS, Al-Maawali A, Srinivasan VM, Al-Thihli K, Schaefer GB, Davis M, Tonduti D, Doneda C, Marten LM, Mühlhausen C, Gomez M, Lamantea E, Mena R, Nizon M, Procaccio V, Begtrup A, Telegrafi A, Cui H, Schulz HL, Mohr J, Biskup S, Loos MA, Aráoz HV, Salpietro V, Keppen LD, Chitre M, Petree C, Raymond L, Vogt J, Sawyer LB, Basinger AA, Pedersen SV, Pearson TS, Grange DK, Lingappa L, McDunnah P, Horvath R, Cognè B, Isidor B, Hahn A, Gripp KW, Jafarnejad SM, Østergaard E, Prada CE, Ghezzi D, Gowda VK, Taylor RW, Sonenberg N, Houlden H, Sissler M, Varshney GK, Maroofian R. Clinical, neuroradiological, and molecular characterization of mitochondrial threonyl-tRNA-synthetase (TARS2)-related disorder. Genetics in Medicine. 2023 Nov;25(11):100938.

• Chalkiadaki K, Statoulla E, Zafeiri M, Haji N, Lacaille JC, Powell CM, Jafarnejad SM*, Khoutorsky A*, Gkogkas CG*. Reversal of memory and autism-related phenotypes in Tsc2^+/- mice via inhibition of Nlgn1. Front Cell Dev Biol. 2023 May 24;11:1205112. *Joint corresponding authors

• Hoang HD, Naeli P, Alain T, Jafarnejad SM. Mechanisms of impairment of interferon production by SARS-CoV-2. Biochem Soc Trans. 2023 Jun 28;51(3):1047-1056.

• Hoang HD, Said A, Vaidya N, Gilchrist VH, Malone K, Kabilan U, Topshee S, Xiang X, Yang AD, Olagnier D, Mossman K, Beug ST, Jafarnejad SM, Workenhe ST, Graber TE, Alain T. Adaptation of transgene mRNA translation boosts the anticancer efficacy of oncolytic HSV1. J Immunother Cancer. 2023 Mar;11(3):e006408.

• Anadolu MN, Sun J, Kailasam S, Chalkiadaki K, Krimbacher K, Li JT, Markova T, Jafarnejad SM, Lefebvre F, Ortega J, Gkogkas CG, Sossin WS. Ribosomes in RNA Granules Are Stalled on mRNA Sequences That Are Consensus Sites for FMRP Association. J Neurosci. 2023 Apr 5;43(14):2440-2459.

• Chalkiadaki K, Hooshmandi M, Lach G, Statoulla E, Simbriger K, Amorim IS, Kouloulia S, Zafeiri M, Pothos P, Bonneil É, Gantois I, Popic J, Kim SH, Wong C, Cao R, Komiyama NH, Atlasi Y, Jafarnejad SM*, Khoutorsky A*, Gkogkas CG*. Mnk1/2 kinases regulate memory and autism-related behaviours via Syngap1. Brain. 2023 May 2;146(5):2175-2190. *Joint corresponding authors

2022

• Escós A, Martín-Gómez J, González-Romero D, Díaz-Mora E, Francisco-Velilla R, Santiago C, Cuezva JM, Domínguez-Zorita S, Martínez-Salas E, Sonenberg N, Sanz-Ezquerro JJ, Jafarnejad SM, Cuenda A. TPL2 kinase expression is regulated by the p38γ/p38δ-dependent association of aconitase-1 with TPL2 mRNA. Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2204752119.

• Xu Z, Choi JH, Dai DL, Luo J, Ladak RJ, Li Q, Wang Y, Zhang C, Wiebe S, Liu ACH, Ran X, Yang J, Naeli P, Garzia A, Zhou L, Mahmood N, Deng Q, Elaish M, Lin R, Mahal LK, Hobman TC, Pelletier J, Alain T, Vidal SM, Duchaine T, Mazhab-Jafari MT, Mao X, Jafarnejad SM*, Sonenberg N*. SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2204539119. *Joint corresponding authors

• Naeli P, Winter T, Hackett AP, Alboushi L, Jafarnejad SM. The intricate balance between microRNA-induced mRNA decay and translational repression. FEBS J. 2023 May;290(10):2508-2524.

• Tamaddondoust RN, Wang Y, Jafarnejad SM, Graber TE, Alain T. The highs and lows of ionizing radiation and its effects on protein synthesis. Cell Signal. 2022 Jan;89:110169.

2021

• Alboushi L, Hackett AP, Naeli P, Bakhti M, Jafarnejad SM. Multifaceted control of mRNA translation machinery in cancer. Cell Signal. 2021 Aug;84:110037.

• Mayya VK, Flamand MN, Lambert AM, Jafarnejad SM, Wohlschlegel JA, Sonenberg N, Duchaine TF. microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development. Nucleic Acids Res. 2021 May 21;49(9):4803-4815.

• Zhang X, Chapat C, Wang P, Choi JH, Li Q, Luo J, Wiebe S, Kim SH, Robichaud N, Karam IF, Dai D, Hackett AP, Lin R, Alain T, Yang L*, Jafarnejad SM*, Sonenberg N*. microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP. Mol Cell. 2021 Mar 18;81(6):1187-1199.e5. *Joint corresponding authors

• Kim SH, Choi JH, Wang P, Go CD, Hesketh GG, Gingras AC, Jafarnejad SM*, Sonenberg N*. Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation. Mol Cell. 2021 Jan 21;81(2):398-407.e4. *Joint corresponding authors

• Simbriger K, Amorim IS, Lach G, Chalkiadaki K, Kouloulia S, Jafarnejad SM*, Khoutorsky A*, Gkogkas CG*. Uncovering memory-related gene expression in contextual fear conditioning using ribosome profiling. Prog Neurobiol. 2021 Feb;197:101903. *Joint corresponding authors

2020

• Mousavizadeh R, Hojabrpour P, Eltit F, McDonald PC, Dedhar S, McCormack RG, Duronio V, Jafarnejad SM, Scott A. β1 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells. Sci Rep. 2020 Jul 28;10(1):12644.

• Atlasi Y*, Jafarnejad SM*, Gkogkas CG, Vermeulen M, Sonenberg N, Stunnenberg HG. The translational landscape of ground state pluripotency. Nature Communications. 2020 Apr 1;11(1):1617. *Joint 1st authors

• Simbriger K, Amorim IS, Chalkiadaki K, Lach G, Jafarnejad SM, Khoutorsky A, Gkogkas CG. Monitoring translation in synaptic fractions using a ribosome profiling strategy. J Neurosci Methods. 2020 Jan 1;329:108456.

2019

• Kouloulia S, Hallin EI, Simbriger K, Amorim IS, Lach G, Amvrosiadis T, Chalkiadaki K, Kampaite A, Truong VT, Hooshmandi M, Jafarnejad SM, Skehel P, Kursula P, Khoutorsky A, Gkogkas CG. Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity. Cell Reports. 2019 Dec 10;29(11):3620-3635.e7.

• Hoang HD, Graber TE, Jia JJ, Vaidya N, Gilchrist VH, Xiang X, Li W, Cowan KN, Gkogkas CG, Jaramillo M, Jafarnejad SM, Alain T. Induction of an Alternative mRNA 5′ Leader Enhances Translation of the Ciliopathy Gene Inpp5e and Resistance to Oncolytic Virus Infection. Cell Reports. 2019 Dec 17;29(12):4010-4023.e5.

• Hassanzadeh G, Naing T, Graber T, Jafarnejad SM, Stojdl DF, Alain T, Holcik M. Characterizing Cellular Responses During Oncolytic Maraba Virus Infection. Int J Mol Sci. 2019 Jan 29;20(3):580.